fructokinase

fructokinase is an enzyme that initiates fructose metabolism by converting fructose into fructose-1-phosphate. fructokinase is the first step in the metabolism of fructose, rapidly trapping it in cells—especially in the liver. Unlike glucose, this process bypasses key regulatory checkpoints, often leading to cellular energy depletion, fat accumulation, and uric acid production. Because of its central role in driving the harmful effects of fructose, inhibiting fructokinase is a key strategy being explored to protect metabolic health.