Free FC Kit gift bottle with your first SugarShield subscription!   Expiry:   Code: kitgift

  Free FC Kit gift bottle with your first SugarShield subscription!   Expiry:   Code: kitgift

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Much of the information presented here may be new to you, as it is based on recent science. Our Frequently Asked Questions section may provide the answers you seek. Our posts explore various fructose-related topics in detail. Alternatively, you can always reach out via chat, and we’ll be happy to assist you one-on-one.

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Delve into the complex web of how fructose impacts our health.

Luteolin blocks the enzyme enabling Fructose metabolism

"Luteolin is a potent fructokinase inhibitor."  Andres-Hernando, A., Li, N., Cicerchi, C. et al. Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice. Nat Commun 8, 14181 (2017). https://doi.org/10.1038/ncomms14181

we back it up with a money-back guarantee

We provide a 30-day money-back guarantee for your initial kit purchase. Please be aware that shipping costs are non-refundable, and as a matter of health and safety, we cannot accept returns for opened supplement products. It's essential to acknowledge that the...

Luteolin blocks Fructose

Luteolin was recently found to block the enzyme fructokinase, which is the enzyme that enables fructose to enter the cell. By inhibiting it, fructose — whether dietary or synthesized — is unable to enter the cell and cause it stress. This effectively halts ongoing...

synthesize Fructose

Yes, our tissues know how to MAKE fructose in certain conditions throughout the body, even in the brain. This discovery only occurred recently, but explains the difficulty we have had in finding the true culprit for weight gain. Turns out that all our suspicions about...

root cause of metabolic decline

The past 150 years has seen a global decline in health which has been labeled as metabolic syndrome. Symptoms range from lack of energy, brain fog, obesity, diabetes, hypertension, heart disease, fatty liver, cancer, Alzhiemers Disease and much more. Recent science is...

fructokinase

Fructokinase is an enzyme that converts fructose into fructose-1-phosphate, facilitating its entry into cells. Luteolin can inhibit this enzyme, effectively blocking fructose from entering cells.

Fructose may be the root cause of metabolic ailments

"Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome." Hannou SA, Haslam DE, McKeown NM, Herman MA. Fructose metabolism and metabolic disease. J Clin Invest. 2018 Feb 1;128(2):545-555. doi: 10.1172/JCI96702. Epub 2019 Feb 1....

protect against the development of Alzheimers-like disease

Daily JW, Kang S, Park S. Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti-inflammatory activity, and the gut microbiota-liver-brain axis. Biofactors. 2021 Mar;47(2):218-231. doi: 10.1002/biof.1703. Epub 2020 Dec 21. PMID:...

Luteolin alleviates non-alcoholic fatty liver disease

Xia Liu, Runzhou Sun, Zhaozhen Li, Ruixin Xiao, Pengfei Lv, Xiangrong Sun, Mark A. Olson, Yanling Gong, Luteolin alleviates non-alcoholic fatty liver disease in rats via restoration of intestinal mucosal barrier damage and microbiota imbalance involving in gut-liver...

Luteolin exerts cardioprotective effects

Pan Q, Liu Y, Ma W, Kan R, Zhu H and Li D (2022) Cardioprotective Effects and Possible Mechanisms of Luteolin for Myocardial Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis of Preclinical Evidence. Front. Cardiovasc. Med. 9:685998. doi:...

Luteolin attenuates angiotensin II‑induced renal damage

Liu, Y., Yang, Q., Li, S., Luo, L., Liu, H., Li, X., & Gao, Z. (2021). Luteolin attenuates angiotensin II‑induced renal damage in apolipoprotein E‑deficient mice. Molecular Medicine Reports, 23, 157. https://doi.org/10.3892/mmr.2020.11796

Luteolin may be a key, newfound remedy for elevated blood pressure.

Gao HL, Yu XJ, Feng YQ, Yang Y, Hu HB, Zhao YY, Zhang JH, Liu KL, Zhang Y, Fu LY, Li Y, Qi J, Qiao JA, Kang YM. Luteolin Attenuates Hypertension via Inhibiting NF-κB-Mediated Inflammation and PI3K/Akt Signaling Pathway in the Hypothalamic Paraventricular Nucleus...

luteolin ameliorates diet-induced obesity and its comorbidities

Kwon EY, Choi MS. Luteolin Targets the Toll-Like Receptor Signaling Pathway in Prevention of Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice. Nutrients. 2018 Oct 3;10(10):1415. doi: 10.3390/nu10101415. PMID: 30282902; PMCID: PMC6213163.

lead[s] to increased testosterone production

Martin LJ, Touaibia M. Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism. Antioxidants (Basel). 2020 Mar 13;9(3):237. doi: 10.3390/antiox9030237. PMID: 32183155; PMCID: PMC7139932.

Luteolin possesses potent estrogen agonist activity

Nordeen SK, Bona BJ, Jones DN, Lambert JR, Jackson TA. Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin. Horm Cancer. 2013 Oct;4(5):293-300. doi: 10.1007/s12672-013-0150-1. Epub 2013 Jul 9. PMID: 23836117; PMCID: PMC3851288.

Luteolin alleviates polycystic ovary syndrome

Huang Y, Zhang X. Luteolin alleviates polycystic ovary syndrome in rats by resolving insulin resistance and oxidative stress. Am J Physiol Endocrinol Metab. 2021 Jun 1;320(6):E1085-E1092. doi: 10.1152/ajpendo.00034.2021. Epub 2021 Apr 26. PMID: 33900851.

Luteolin reduces both physical and mental effects of chronic fatigue

Duan FF, Guo Y, Li JW, Yuan K. Antifatigue Effect of Luteolin-6-C-Neohesperidoside on Oxidative Stress Injury Induced by Forced Swimming of Rats through Modulation of Nrf2/ARE Signaling Pathways. Oxid Med Cell Longev. 2017;2017:3159358. doi: 10.1155/2017/3159358. Epub...

Luteolin blocks the metabolism of Fructose Sugar

"we have observed that luteolin is a potent fructokinase inhibitor in vitro (IC50: 11.2 μM) and in human proximal tubular cells that express fructokinase" "we observed that luteolin induced a significant elevation in urinary fructose levels" Andres-Hernando, A., Li,...

human clinical trials

Effects of Natural Supplement Containing Chlorogenic Acid and Luteolin on Cardio-metabolic Risk Factors https://beta.clinicaltrials.gov/study/NCT03444558

TART CHERRY EXTRACT can reduce URIC ACID levels

Martin KR, Coles KM. Consumption of 100% Tart Cherry Juice Reduces Serum Urate in Overweight and Obese Adults. Curr Dev Nutr. 2019 Feb 25;3(5):nzz011. doi: 10.1093/cdn/nzz011. PMID: 31037275; PMCID: PMC6483050.

amount and speed of carbohydrate intake are crucial factors

Kanbay M, Guler B, Ertuglu LA, Dagel T, Afsar B, Incir S, Baygul A, Covic A, Andres-Hernando A, Sánchez-Lozada LG, Lanaspa MA, Johnson RJ. The Speed of Ingestion of a Sugary Beverage Has an Effect on the Acute Metabolic Response to Fructose. Nutrients. 2021 Jun...

It then causes the creation of URIC ACID

Cirillo P, Gersch MS, Mu W, Scherer PM, Kim KM, Gesualdo L, Henderson GN, Johnson RJ, Sautin YY. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol. 2009 Mar;20(3):545-53. doi:...

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